Mitochondrial Energy Optimization
CoQ10 + NAD+ work synergisticallyin the electron transport chain — optimizing ATP synthesis and reducing oxidative stress beyond what either ingredient achieves
Renew365
$89.00 — available on subscription from $79.00 / month
The Complete Daily Mitochondrial & Longevity Stack
Designed to Pair with UCOS & Triple Power Methylene Blue
Renew365 is a clinically dosed, mechanism driven longevity tablet combining four synergistic ingredients at therapeutic doses to support cellular energy, NAD+ metabolism, mitochondrial function, and healthy aging pathways.* It is designed as the cornerstone daytime tablet within Best 365 Labs’ cellular optimization ecosystem, pairing seamlessly with Triple Power Methylene Blue and the UCOS system.
In every 2 tablet dose this advanced formula delivers:
- 200 mg NAD+
- 200 mg CoQ10
- 100 mg Pterostilbene
- 40 mg Fisetin
Renew365 key benefits:
- Supports cellular energy & ATP production*
- Promotes healthy NAD+ levels & sirtuin activation*
- Enhances mitochondrial function & electron transport*
- Senolytic & healthy aging support*
Independent, 3rd Party lab tested
Why It Works
Longevity Gene Activation
Pterostilbene + NAD+ clinically raises NAD+ levels by 40–90% and activates SIRT1 longevity genes for DNA repair and mitochondrial renewal*
Senolytic Cellular Removal
Fisetin supports the body's natural clearance of senescent "zombie" cells — the aging, dysfunctional cells that accumulate over time and drive systemic cellular decline*
Quad Action Formula
NAD+ fuels, CoQ10 powers, Pterostilbene activates longevity genes, Fisetin clears damaged cells — four clinically dosed ingredients targeting healthy aging from every angle*
Who Should Consider This
Adults 35+ focused on healthy aging & cellular longevity*
Anyone experiencing energy decline linked to mitochondrial aging*
Biohackers seeking clinically dosed longevity support*
Those wanting to amplify results from Methylene Blue protocols*
What To Expect
Days 1-7:
Improved cellular energy & reduced oxidative fatigue*
Weeks 2-4:
Enhanced mental clarity, stamina & metabolic
Months 2-3:
Activated longevity pathways & improved
Ongoing
Cumulative anti-aging, DNA repair & longevity support*
Better Together
Pair with Triple Power Methylene Blue for rapid mitochondrial activation — Methylene Blue ignites the system, Renew365 sustains it all day.*
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Do not use if pregnant or nursing. Methylene Blue may cause urine to appear blue or green — this is normal. Not for use in patients with G6PD deficiency. Do not exceed 60mg total Methylene Blue per day.
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What are the benefits of NAD+?
NAD – 200 mg/day
- Essential cofactor for cellular energy production via NADH → electron transport chain.
- Fuels all seven sirtuin enzymes (SIRT1–7) for DNA repair, genomic stability, and mitochondrial biogenesis.*
- Works synergistically with pterostilbene to increase whole‑blood NAD+ levels by 40–90% in clinical trials.
- Provides electrons to CoQ10 in Complex I of the mitochondrial respiratory chain.*
What are the benefits of Pterostilbene?
Pterostilbene – 100 mg/day
- Potent SIRT1 activator with 80% bioavailability (4× higher than resveratrol).
- Clinically proven synergy with NAD precursors: NR + pterostilbene combination safely raised NAD+ by 90% and improved diastolic blood pressure, liver enzymes (ALT), and cholesterol metabolism in elderly adults.
- Supports healthy glucose metabolism, cognitive function, and cardiovascular health.*
- Superior membrane permeability and longer half life than resveratrol ensures sustained sirtuin activation.*
What are the benefits of CoQ10?
CoQ10 (Ubiquinone) – 200 mg/day
- Central electron carrier in mitochondrial Complexes I, II, and III, accepting electrons from NADH and FADH₂ to drive ATP synthesis.*
- Maintains CoQH₂/CoQ ratio, a key sensor of metabolic status and mitochondrial efficiency.*
- Dual antioxidant role: reduces ROS at the mitochondrial membrane and regenerates vitamin E and vitamin C.*
- Combined CoQ10 + NAD creates synergistic enhancement of mitochondrial function beyond single supplementation.*
- Naturally depletes with age and statin use; supplementation at 200 mg/day restores optimal tissue levels.*
What are the benefits of Fisetin?
Fisetin – 40 mg/day
- Emerging senolytic flavonoid that supports the body’s natural clearance of senescent (“zombie”) cells.*
- Works synergistically with other flavonoids and NAD+ boosting compounds for enhanced cellular health benefits.*
- Supports brain health, neuroprotection, and healthy inflammatory pathways.*
- Daily low dose fisetin (40 mg) provides gentle ongoing senotherapeutic support, distinct from high dose intermittent senolytic protocols.*
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I like the tablet form of Methylene Blue, because it does not discolor your teeth, gums, mouth, or lips. However, you might find your pee a slight shade of blue. After taking these pills, I definitely feel more alert, better overall physical health, an uptick in mental happiness, and seem to have more drive to accomplish chores.